They studied the immune cell composition in mice that express human FTD-mutant TauP301S and develop Tau tangle pathology, neuroinflammation (microglia and astrocyte activation), and neuronal loss in the hippocampal formation and other parts of the brain (TE4 line, derived from PS19 line), and in mice that develop amyloid plaque pathology (A/PE4 or 5xE4 lines, derived from APP/PS1 and 5xFAD lines) that show less neuronal damage and milder neuroinflammation. Here, MAPT is linked to frontotemporal dementia.