SPHK1 and T-cell large granular lymphocyte leukemia: LeBlanc et al., found that SphK inhibition by SKI-178 led to ceramide production, phosphorylations CDK1 and Bcl-2, as well as decreased JAK-STAT signaling, and eventually causing cell cycle arrest and apoptosis in natural killer-large granular lymphocyte leukemia cells [13].