In this research, samples of lung adenocarcinoma were interrogated with TME-related genes, among which high expression of PLK1, LDHA, FURIN, FSCN1, and RAB27B was correlated with poor OS, while high expression of MS4A1 was correlated with longer OS compared with the MS4A1 low expression. This evidence concerns the gene MS4A1 and lung adenocarcinoma.