Furthermore, we also found that PLK1, LDHA, FURIN, FSCN1, and RAB27B were increased in NSCLC cancerous cell lines compared with that in normal human bronchial epithelium cell line BEAS-2B, MS4A1 was down-regulated in lung cancer cells lines (Supplementary Fig. S2C,D). The gene discussed is RAB27B; the disease is lung cancer.