Numerous studies have explored potential biomarkers for SJS/TEN, including granulysin19, Fas ligands (FasL)20, perforin B21,22, microRNA (miRNA)23, annexin A124, S100 calcium-binding protein A2(S100A2)25, CCL-2726,27, IL-1528, galectin-729, RIP330, and high mobility group box 1 protein (HMGB1)31. This evidence concerns the gene HMGB1 and toxic epidermal necrolysis.