Interestingly, the expression of ECT2, FGD6, MMP14, and SLC2A1 were statistically different in the patients with different tumor stage, which implied that ECT2, FGD6, MMP14, and SLC2A1 might be associated with the development of PC (Supplementary Fig. 5). This evidence concerns the gene SLC2A1 and pachyonychia congenita.