In the training cohort, random survival forest analysis helped identify the most appropriate genes (i.e., SLC2A1, MMP14, TOP2A, MBOAT2, ANLN, ECT2, SLC22A3, and FGD6) related to survival of PC patients, and an OSPM-related signature was identified (Fig. 7A). The gene discussed is ANLN; the disease is pachyonychia congenita.