In the training cohort, random survival forest analysis helped identify the most appropriate genes (i.e., SLC2A1, MMP14, TOP2A, MBOAT2, ANLN, ECT2, SLC22A3, and FGD6) related to survival of PC patients, and an OSPM-related signature was identified (Fig. 7A). This evidence concerns the gene ECT2 and pachyonychia congenita.