CD79A and infection: In contrast, plasma anti-spike binding IgA increased following infection in both groups (Fig. 2e), although again to a greater extent in previously-naive (ancestral, 5.0-fold, p < 0.0001; BA.2, 6.6-fold, p < 0.0001; BA.5, 5.5-fold, p < 0.0001) compared to previously-infected individuals (ancestral, 1.5-fold, p = 0.03; BA.2, 1.7-fold, p = 0.01; BA.5, 1.5-fold, p = 0.01).