In SARS-CoV-2 naive individuals, a significant increase following omicron infection was seen in peripheral IFN-γ ELISpot responses to peptide pools representing ancestral S1 (1.9-fold, p < 0.0001) and S2 (1.8-fold, p = 0.002), BA.1 S1 (2.7-fold, p < 0.0001) and S2 (2.2-fold, p = 0.0006), and BA.2 S1 (2.6-fold, p < 0.0001) and S2 (1.8-fold, p = 0.002; Fig. 4a, b). The gene discussed is IFNG; the disease is infection.