Expression of the cytolytic enzyme granzyme B in spike-specific CD8+ T cells did not change significantly after omicron infection, however, expression levels were significantly higher in previously-infected individuals at both time points (p = 0.0002 and p = 0.0042, Fig. 7c), to a level similar to that seen in CMV-specific T cells. The gene discussed is GZMB; the disease is infection.