In addition, we observed that the AMPK inhibitor reduced mitochondrial damage and mitochondrial permeability transition (MPT), increased lactate dehydrogenase (LDH) activity levels and the proportion of propidium iodide (PI)‐positive cells, promoted iron concentration levels, and suppressed glutathione (GSH) and glutathione peroxidase 4 (GPX4) protein expressions in NSCLC with upregulated TRIM11 gene expression (as shown in Figure 6A–G). The gene discussed is TRIM11; the disease is non-small cell lung carcinoma.