We analyzed the EDR/ESR predictions and found rs73347525 overlaps an islet-specific EDR region and most strongly perturbs a motif for ZNF415 (SI Appendix, Table S3), where the risk allele (A) results in decreased binding—suggesting that rs73347525 may perturb ZNF415 binding, resulting in increased DLK1 expression and increased T2D risk. The gene discussed is ZNF415; the disease is type 2 diabetes mellitus.