RFX6 and type 2 diabetes mellitus: We calculated the overlap of the 94 candidate causal SNPs with predicted TFBSs (based on motifs; SI Appendix, Table S3 and Materials and Methods) and found these SNPs were enriched (false discovery rate [FDR] < 5%) in RFX family-binding sites, consistent with previous studies that report RFX6 as an important islet TF for T2D genetic risk (20, 36).