To investigate the correlation between LAMP family members genetic alteration with LGG, we used the cBioPortal online tool to collect 3 studies Brain Lower Grade Glioma (TCGA, Pan Cancer Atlas), Brain Lower Grade Glioma (TCGA, Firehose Legacy), Low-Grade Gliomas (UCSF, Science 2014) data of a total of 1105 samples from the TCGA dataset of LGG for analysis. This evidence concerns the gene LAMP3 and central nervous system cancer.