Compared with paclitaxel, nanoparticle albumin-bound paclitaxel (Nab-PTX) may distribute tumors more efficiently and does not require dexamethasone pretreatment.[13,14] But there is still no study to investigate sintilimab and Nab-PTX plus platin in the treatment of metastatic ESCC. This evidence concerns the gene ALB and esophageal squamous cell carcinoma.