IL4 and Down syndrome: Compared with conventional western medicine, acupoint application can effectively improve the effective rates of clinical comprehensive (risk ratio [RR] 1.13, 95% confidence interval [CI] 1.06–1.20, P = .0003), syndrome (RR 1.13, 95% CI 1.03–1.24, P = .009), and interleukin-4 (IL-4) (mean differences 2.62, 95% CI 1.96–3.28, P < .00001) in the treatment of UC, and reduce interferon-γ (mean differences −5.38, 95% CI −6.81 to −3.94, P < .00001).