SQSTM1 and amyotrophic lateral sclerosis: Furthermore, the mutation of p62 identified as causative in the neurodegenerative disease amyotrophic lateral sclerosis (ALS), K102E, impairs p62 DLC formation and autophagy.[44] These findings suggest that p62 has evolutionarily acquired the ability to respond to oxidative stress in vertebrates, and that impairment of this response is associated with age‐related neurodegeneration.[50]