This suggests that p62 is necessary for aggregate formation as well as misfolded protein degradation, which is further supported by evidence that Ref(2)P is required for protein aggregate formation in Drosophila brain.[80] This role of p62 may also be neuroprotective, as pre‐fibrillar tau oligomers are thought to represent the toxic species in AD, rather than fibrillar tau.[81]. The gene discussed is SQSTM1; the disease is Alzheimer disease.