SQSTM1 and proteostasis deficiencies: In proteinopathies, oxidative stress can induce the formation of pathogenic forms of a protein, which can have a cytotoxic effect and further increase ROS overproduction.[78] p62 may be of particular interest as a target for preventing neurodegeneration by upregulating ROS‐induced autophagy, as p62 knockout mice show hyperphosphorylation and aggregation of tau, which is a key hallmark of AD.