TP53 and neoplasm: It has been proved in tumour cell experiments that P53 can travel from the nucleus to the cytoplasm and then bind to Bcl‐2 (apoptosis inhibitor), inhibiting Bcl‐2 and activating Bax/Bak (members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis),33 and Bak activation is associated with p53 ser15 phosphorylation.34