It has been proved in tumour cell experiments that P53 can travel from the nucleus to the cytoplasm and then bind to Bcl‐2 (apoptosis inhibitor), inhibiting Bcl‐2 and activating Bax/Bak (members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis),33 and Bak activation is associated with p53 ser15 phosphorylation.34 This evidence concerns the gene BAK1 and neoplasm.