If the patient has only EM, increase in body temperature, and laboratory-confirmed LD, but there are no characteristic manifestations of HGA (manifestations of pharyngitis, changes in chest X-ray image, changes in bilirubin and ALT with the tick bite in history), the prediction of HGA presence is 6.8%, and the probability of HGA diagnosis is minimal. This evidence concerns the gene GPT and erythema multiforme.