Not many reports on single-nucleotide polymorphism have been reported for PCOS susceptibility from the region of southern India; hence, the present study was examined to understand the possible role of rs2414096 of CYP19 gene and its association with hyperandrogenism in women with PCOS among the residents from the state of Karnataka, India. The gene discussed is CYP19A1; the disease is polycystic ovary syndrome.