WRN and Werner syndrome: During the past decades, the International Registry of Werner Syndrome (Seattle, USA) identified progeroid loci that highlight major roles in DNA damage repair and response: WRN (RecQ helicase) [17], LMNA (nuclear structure and chromatin interaction) [2], POLD1 (DNA polymerase delta) [10], SPRTN (recruitment of translational DNA polymerase eta) [9], ERCC4 (nucleotide excision repair) [13], MDM2 (an inhibitor of p53) [11], CTC1 (telomere replication) [16], and SAMHD1 (regulation of dNTP pools) [8].