PTGS2 and COVID-19: The hypothesis that NSAIDs may possibly have a protective effect in COVID-19 if used regularly during the first few days of symptoms has recently been advanced by Perico et al., who propose a home treatment protocol that includes the use of NSAIDs, particularly COX-2-selective NSAIDs, in the first 3–4 days from the onset of symptoms (continued for longer if symptoms persist) (Perico et al. 2022).