MMP3 encodes a matrix metalloproteinase, which is known to play a critical role in maintaining extracellular matrix (ECM) homeostasis by breaking down MMP3-sensitive ECM components in physiological and pathological processes, such as liver fibrosis (Juran et al. 2011; Miyahara et al. 2000). The gene discussed is MMP3; the disease is Hepatic fibrosis.