Compared to melanoma cells in the epidermis, melanoma cells located in the dermal compartment had significantly higher expression of proteins involved in remodeling of the extracellular matrix (e.g., DPT, COL1A2, COL1A1, COL3A1, COL6A1, DCN, TGFBI, PRELP, DCN, FGA, FN1, and LUM) (Fig 7E). The gene discussed is COL3A1; the disease is melanoma.