These findings indicate that MKP‐1 can induce the release of IL‐4 and inhibit IL‐6 and IL‐10 secretion without impacting levels of IL‐1β expression in BV2 microglia and that MKP‐1 influences the release of both pro‐ and anti‐inflammatory factors, which contribute to the development of AD. Here, IL4 is linked to Alzheimer disease.