However, it has been recognized that the “AD‐like phenocopy” is most prevalent in the oldest patients and may be best explained by a mix of age‐related pathologies (e.g., hippocampal sclerosis, limbic‐predominant age‐related TAR‐DNA binding protein 43 [TDP‐43] encephalopathy, argyrophilic grain disease, or tangle‐predominant dementia) that preferentially target the limbic system, resulting in a memory‐predominant presentation that may be misdiagnosed as AD.26, 27, 28. The gene discussed is TARDBP; the disease is Encephalopathy.