TMB (P value = 0.00101), PD-L1 expression (P value = 0.0062), line of treatment (P value = 0.0058), smoking status (P value = 0.00108), treatment type (P value = 0.0009) and PTPRD (P value = 0.0441) were significantly related to the PFS in advanced NSCLC patients with ICIs treatment (Figures 1D–1H, 3B). This evidence concerns the gene PTPRD and non-small cell lung carcinoma.