The Kaplan–Meier survival curves showed the mutation of PTPRD was associated with the PFS (P = 0.0441, HR = 1.548 (1.071 – 2.238)) and OS (P = 0.0086, HR = 1.889 (1.282 – 2.782)) in NSCLC with ICIs treatment. This evidence concerns the gene PTPRD and non-small cell lung carcinoma.