F7 and hemophilia B: Besides those known drugs/treatments used in the training set, the majority of the remaining 7 drugs/treatments on the list are supported by published research and have the potential to treat hemophilia B. For example, the activated human-derived coagulation factor VII (i.e., factor VIIa) or the recombinant activated factor VII (i.e., rFVIIa) is one of the proteins that can cause blood clots as an important part of the blood coagulation regulatory network (as shown in the Fig. 4).