Previous publications have highlighted that point mutations or deletions in similar regions of the MyHC molecule lead to muscle phenotype and dilated cardiomyopathy and/or skeletal myopathy,30, 31, 32, 33, 34, 35, 36, 37 including Arg1193His, Arg1193Ser, Ser1297Val, Ala1332Thr, Arg1344Trp, Glu1426Lys, Arg1434Cys, Lys1444Glu, Lys1729del, and K1784del. This evidence concerns the gene MYH6 and skeletal muscle disorder.