Here, in the presence of myopathy‐related RYR1 mutations, we mainly observed three additional (Thr1309‐P, Ser1362‐P, and Lys1410‐Ac on the β/slow MyHC) and six missing (Lys35‐Ac, Lys663‐Ac, Lys763‐Ac, Lys1171‐Ac, Lys1360‐Ac, and Lys1733‐Ac on the type IIa MyHC) PTMs. The gene discussed is MYH6; the disease is myopathy.