In turn, SIRT2 inhibition is neuroprotective in AD, PD, and HD mouse models and delays the progression of neurodegeneration (Bai et al., 2022; Biella et al., 2016; Chen et al., 2015; Chopra et al., 2012; de Oliveira et al., 2017; Outeiro et al., 2007; Silva et al., 2017; Wang et al., 2020). This evidence concerns the gene SIRT2 and Huntington disease.