Consistent with a previous report of an increased SIRT2:SIRT1 ratio in postmortem AD individuals (Theendakara et al., 2013), we observed the SIRT2:SIRT1 ratio was higher both in the cortex and hippocampus of APP/PS1 mice compared to their littermates (wild‐type, WT) at the age of 6 months (Figure 1c,d). Here, SIRT1 is linked to Alzheimer disease.