As compared to populations 1 and 2, the ARKC genes were significantly upregulated in KC populations 4 and 5, including Got1, Dapk1, Trim25, Hbegf, Dyrk2, Abca1, Lpcat2, Cd83, and Bcl2a1b. The gene discussed is DYRK2; the disease is keratoconus.