In KC populations 4 and 5, the expression of ARKC genes, such as Got1, Dapk1, Dyrk2, Rhob, Hbegf, Cd83, Lpcat2, Ncoa4, Hes1, and Bcl2a1b, showed a highly positive correlation with the expression of chemokine and pro‐inflammatory cytokine genes, including Ccl2, Tnf, and Il1b. The gene discussed is HBEGF; the disease is keratoconus.