MFN2 and neoplasm: According to recent research conducted by Ding and co-workers, promoting MFN2 mediated mitochondrial fusion induces a similar metabolic transition from glycolysis to OXPHOS in cardiomyocytes and tumor cells (Ding et al., 2022a), charactered by decrease in the oxygen consumption rate (OCR)-to-extracellular acidification rate (ECAR) ratio.