MFN2 and neoplasm: Overexpression of Mfn-2, inhibition of Drp-1, or knockdown of Drp-1 can reduce the proliferation of cancer cells and induce increased apoptosis of tumor cells, thereby shrinking tumors in lung, breast, and colon cancer (Inoue-Yamauchi and Oda, 2012; Rehman et al., 2012; Zhao et al., 2013).