Furthermore, to critically analyze the role of PTEN-mediated cell death initiation in B-cell lymphoma, irrespective of the infectious condition, we have tested the efficacy of PTEN against a non-infected B-cell lymphoma cell line, BJAB, where PTEN is totally deleted with KSHV-infected B-cell lymphoma lines. The gene discussed is PTEN; the disease is B-cell non-Hodgkin lymphoma.