TP53 and lung cancer: Treatment of lung cancer cells with actinomycin D and nutlin-3a primes cells for production of type I IFN by upregulating STING in a p53-dependent manner (Krześniak et al., 2020; Pu et al., 2021), suggesting a critical role of p53 in regulating STING levels to allow for type I IFN-mediated immune responses.