PVT1 can bind to different proteins to exert oncogenic effects, and in gastric cancer, PVT1 can bind to the signal transduction activator STAT3 to ensure that it is not degraded, thus activating the STAT3 signaling pathway and thus increasing VEGFA in gastric cancer, thus activating the STAT3 signaling pathway and increasing the expression of VEGFA to promote gastric cancer angiogenesis. This evidence concerns the gene STAT3 and gastric cancer.