CELSR1 and lung adenocarcinoma: For lung adenocarcinoma (LUAD), miRNAs affect cancer cells and ECs bidirectionally; for example, miR-629-5p in lung adenocarcinoma transfers to endothelial cells, and by inhibiting CELSR1, which is lower in endothelial cells in invasive LUAD (a miR-30a-5p, a non-canonical cadherin, increases endothelial monolayer permeability, while overexpression of miR-30a-5p in endothelial cells inhibited tumor development (Li et al., 2020b; Tao et al., 2021).