Cancer stem-like cells, also known as CD90+ hepatocellular carcinoma cells, are enriched in lncRNA H19, which can be released by encapsulating in exosomes and then transported to endothelial cells, promoting the expression of the angiogenic factor VEGF in endothelial cells and thus regulating hepatocellular carcinoma angiogenesis (Conigliaro et al., 2015). This evidence concerns the gene H19 and hepatocellular carcinoma.