CASP3 and central nervous system cancer: Additionally, LINC-CCAT2 was found to be highly expressed in glioma cells U87-MG and could be transferred to HUVECs to activate the production of the angiogenic factors VEGFA and TGFβ, while inhibiting the expression of the apoptotic molecules Bax and caspase-3, thus promoting angiogenesis and inhibiting apoptosis in glioma cells (Lang et al., 2017b).