In recent years, numerous studies have demonstrated that lncRNAs not only participate in the development of cardiovascular diseases such as atherosclerosis, hypertension, coronary heart disease, cardiomyopathy, and heart failure, but also play critical roles in many pathological processes of atrial fibrillation (AF) development, such as structural remodeling, electrical remodeling, renin-angiotensin system (RAS) anomalies, and intracellular calcium handling deregulation, among others [[3], [4], [5], [6]]. Here, REN is linked to atrial fibrillation.