Pathological inclusions of the protein tau in neurons and glia characterize several human neurodegenerative diseases including frontotemporal lobar degeneration (FTLD-tau), progressive supranuclear palsy (PSP), chronic traumatic encephalopathy (CTE), and Alzheimer’s disease(Limorenko and Lashuel 2022). The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.