The overexpression of IFITM3 by injecting rAAV-EF1a-IFITM3-P2A-mCherry in the hippocampus of septic mice before recombinant human brain natriuretic peptide treatment can completely cancel the therapeutic effect of recombinant human brain natriuretic peptide on anxiety, exploration, learning, and memory dysfunction in septic mice. This evidence concerns the gene IFITM3 and Anxiety.