Using TUNEL staining and Immunoblot, we observed that overexpression of IFITM3 can induce an increase in the number of apoptosis cells in the hippocampal CA1 region and the expression levels of cleaved Caspase-8 and cleaved Caspase-3 proteins in the hippocampus significantly increased in rhBNP-treated sepsis mice. Here, CASP8 is linked to Sepsis.