Accordingly, a panel of six biomarkers (CRP, plasminogen activator inhibitor-1, homocysteine, aldosterone-to-renin ratio, BNP, and urinary albumin-to-creatinine ratio) was significantly related to heart failure risk, but BNP emerged as one of the key biomarkers in predicting new-onset heart failure risk with incremental predictive utility over traditional risk factors [66]. This evidence concerns the gene REN and heart failure.