#1 ("SGLT-2 inhibitor*" or "sodium-glucose cotransporter 2 inhibitor*" or "dapagliflozin" or "empagliflozin" or "canagliflozin" or "ertugliflozin" or "ipragliflozin" or "remogliflozin" or "tofogliflozin" or "luseogliflozin"):ti,ab,kw #2 ("heart failure" or "cardiac failure" or "congestive heart failure" or "CHF" or "left ventricular dysfunction"):ti,ab,kw #3 #1 AND #2. The gene discussed is SLC5A2; the disease is heart failure.