DIDO1 and obesity due to melanocortin 4 receptor deficiency: By contrast, the prevalence of obesity among female carriers of PTV variants in DIDO1 and SLC12A5 was more than 80%, albeit there were relatively fewer carriers (12 of 14 and 9 of 11 carriers were obese, respectively) (PHeterogeneity = 9.9 × 10−6 and PHeterogeneity = 2.6 × 10−4, respectively) (Table S7).