MC4R and obesity due to melanocortin 4 receptor deficiency: The prevalence of obesity (BMI >30 kg/m2) among carriers of DMG variants in MC4R was 39% (228 of 591) in females and 38% (195 of 518) in males, with ORs of 2.01 [1.68–2.41] and 1.71 [1.41–2.08], respectively (Figures 3A and 3C, Table S7).