Increased L‐2HG has been reported in clear cell renal cell carcinoma due to loss or dysfunction of L‐2HG dehydrogenase (L2HGDH) to convert L‐2HG to α‐KG, which is largely associated with gene deletion on 14q, a region coding for L2HGDH [15]. Here, L2HGDH is linked to clear cell renal carcinoma.