Current immunotherapeutic biomarkers in CRC include: high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) status (7); programmed death-Ligand 1 (PD-L1) expression (16); tumor-infiltrating lymphocytes (TILs) (17) and immune gene signatures that provide information about the tumor’s immune environment and potential response to immunotherapy (18). The gene discussed is CD274; the disease is neoplasm.