Two studies investigate vitamin E to examine the efficacy of lifestyle intervention combined with antioxidant therapy (alpha-tocopherol) versus placebo in children and adolescents with biopsy-confirmed NAFLD, assessing changes in liver histology, inflammation, fibrosis, insulin resistance, and glucose metabolism; and investigating the impact of therapeutic interventions targeting insulin resistance and oxidative stress on serum and histologic markers of liver injury, as well as on patients’ quality of life. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.