This paradoxical role of these anti-CD20s could possibly be explained by the fact that R is known to simultaneously activate pro-survival pathway Akt, which drives lymphomagenesis in GCB, and to downregulate pro-survival pathway NF-kB, which drives lymphomagenesis in ABC but not in GCB (52–54). The gene discussed is AKT1; the disease is aneurysmal bone cyst.