HuR (69) and AUF1 p42 isoform are two factors that regulate transcriptional stability of eIF4E and competitively bind to the mRNA 3'UTR of eIF4E. In malignant tumor specimens with high expression of eIF4E, HuR is up-regulated, and its deletion leads to a decrease in eIF4E levels. This evidence concerns the gene EIF4E and cancer.