Compared to normal tissues, the expression level of E2F1, FOXM1, AGER, ISG15, and KCNMA1 were significantly higher in ccRCC tissues, while the expression level of HADH, ABCB1, PLG and TEK were significantly lower (Supplementary Figure 1). The gene discussed is HADH; the disease is nonpapillary renal cell carcinoma.