On the univariable analysis (Table 2), age (p < 0.001), histologic grade (p < 0.001), T status (p < 0.001), N status (p < 0.001), M status (p < 0.001), AJCC staging (p < 0.001), ER status (p < 0.001), PR status (p = 0.019), HER2 status (p = 0.002), tumor subtype (p < 0.001), receipt of chemotherapy (p = 0.036), and surgery type (p < 0.001) were significantly associated with survival outcomes (all p < 0.05). This evidence concerns the gene ESR1 and neoplasm.