MMP9 and neoplasm: Concomitantly, we found that orlistat treatment or switching from a HFD to a LFD significantly inhibited the expression of VEGF and MMP-9 in tumor tissues of HFD and HFD-LFD mice and decreased serum VEGF levels in HFD mice, indicating that inhibition of FAS by orlistat may restrain the invasive capacity of EC.