HSPG2 and neoplasm: Specifically, the phosphatidylinositol-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway and RAS-RAF-MEK-ERK pathway regulates tumor growth, survival, angiogenesis, and metabolism (7–9); the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway contributes to tumor growth, survival, stemness maintenance, and angiogenesis (7, 10), and the activated phospholipase C (PLC)-PKC pathway promotes tumor growth, survival, and invasiveness (11).