The signaling network reconstructed with these 208 genes linked them functionally around meningioma relevant hubs such as AKT3, CDKN1A, PAK2 and PRKAA1 and revealed functions and pathways including cell cycle progress, differentiation, DNA damage response, mRNA nucleus export, growth factors and fibrosis (all FDR < 0.05; Figure S4). The gene discussed is PAK2; the disease is meningioma.