It is noteworthy that while CHIP overall has been associated with smoking, specific gene associations have been limited to variants in ASXL1. The two genes modeled in the current study, TET2 and JAK2, have not been found to be associated with smoking in large population studies from the UK BioBank and a cohort of cancer patients from Memorial Sloan Kettering Cancer Center (9, 10). The gene discussed is TET2; the disease is cancer.