CPT2 and hepatocellular carcinoma: In HCC tissues and serum of HCC patients, the accumulation of acylcarnitines, which serve as carriers to transport activated LCFA into the mitochondria for beta-oxidation, could be attributed to CPT2 downregulation, leading to the suppression of beta-oxidation and metabolic reprogramming to escape lipotoxicity and promote hepatocarcinogenesis (198).