A decrease of ARSB activity in colorectal cancer cells compared to colonic epithelial cells, demonstrated an increase in cell adhesion, migration, and invasion, through upregulation of MMP9 expression and RhoA activation, which are mediators of cellular motility, implicating a key role of ARSB activity in the metastatic potential of epithelial cells (111). This evidence concerns the gene ARSB and colorectal cancer.