ASAH1 and neoplasm: Suggesting that targeting the enzymes, acid ceramidase and sphingosine kinase, will block the tumor cell’s ability to metabolize ceramide, leading to an increase of pro-apoptotic ceramide levels, which will result in apoptosis (151, 152), growth inhibition (93, 152, 153), and increased sensitivity to radiation (154), and chemotherapeutics (155, 156).