But like MYC and other EBTFs, HIFs are also found to be involved in many other aspects of tumorigenesis, including angiogenesis, the immune response, epigenetic regulation, the epithelial-mesenchymal transition (EMT), etc. An example of HIF as a key driver of tumorigenesis is in clear cell renal cell carcinoma (ccRCC), where mutation in VHL is observed in most cases and leads to aberrant accumulation of HIFs (62). Here, MYC is linked to clear cell renal carcinoma.