Over-consideration mainly occurred in CLL/SLL (accuracy of 75.9% in COSMIC IIA vs. 83.0% in COSMIC IIB), FL (accuracy of 36.4% in COSMIC IIA vs. 54.5% in COSMIC IIB), and LPL/WM (accuracy of 77.3% in COSMIC IIA vs. 79.0% in COSMIC IIB), for which COSMIC IIB showed higher accuracy, while incomplete-consideration mainly occurred in MCL (accuracy of 46.2% in COSMIC IIA vs. 11.5% in COSMIC IIB) and MZBL (accuracy of 11.1% in COSMIC IIA vs. 9.3% in COSMIC IIB), for which COSMIC IIA showed better model performance (Figure 3B). The gene discussed is LPL; the disease is B-cell chronic lymphocytic leukemia.