Abnormalities in ATM, TP53, and CCND1 have been reported in mantle cell lymphoma (MCL) (13–15), while MYD88 (especially MYD88 L265P) and CXCR4 mutations have been identified in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) (16, 17). The gene discussed is MYD88; the disease is Waldenstrom macroglobulinemia.